The CNKSR1 Polyclonal Antibody (PAC002308) is a valuable tool for researchers studying CNKSR1, a key protein involved in cell signaling and cancer development. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to CNKSR1, this antibody enables accurate detection and analysis of the protein in various cell types, making it an essential tool for studies in cancer biology and signaling pathways.CNKSR1, also known as connector enhancer of kinase suppressor of Ras 1, plays a critical role in mediating signal transduction pathways that regulate cell growth, differentiation, and survival.
Dysregulation of CNKSR1 has been associated with various cancers, making it a promising target for cancer research and drug development. Understanding the function of CNKSR1 is essential for uncovering potential therapeutic strategies to target this protein in cancer treatment.Overall, the CNKSR1 Polyclonal Antibody is a reliable tool for researchers investigating the role of CNKSR1 in cancer biology and signaling pathways. Its specificity and sensitivity make it a valuable asset for studies aiming to unravel the molecular mechanisms underlying cancer development and progression.
Antibody Name:
CNKSR1 Antibody
Antibody SKU:
PACO02308
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human CNK1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CNKSR1; CNK1; Connector enhancer of kinase suppressor of ras 1; Connector enhancer of KSR 1; CNK homolog protein 1; CNK1; hCNK1; Connector enhancer of KSR-like
UniProt Protein Function:
CNK1: a RAF-binding multidomain protein required for RAS signaling. Contains several protein-protein interaction domains. Its PH domain interacts with Rho in a GTP-dependent manner. Associates with Rhophilin and RalGDS, Rho and Ras effector molecules. Two alternatively spliced isoforms have been described.Protein type: G protein regulator, misc.; Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p36.11Cellular Component: plasma membrane; cell cortex; intercellular junctionMolecular Function: protein binding, bridgingBiological Process: Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
