The COL13A1 Polyclonal Antibody (PAC007451) is a valuable tool for researchers studying COL13A1, a collagen protein known for its role in cellular adhesion and tissue development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.COL13A1 is a key player in maintaining the structural integrity of tissues, particularly in the skin and musculoskeletal system. Its function in cell adhesion and migration make it crucial for processes like wound healing and tissue repair.
Research on COL13A1's involvement in diseases like cancer, fibrosis, and connective tissue disorders is ongoing, underscoring its importance as a therapeutic target.By using the COL13A1 Polyclonal Antibody, researchers can detect and analyze COL13A1 expression in different cell types, shedding light on its role in health and disease. This antibody is a valuable tool for studies in cell biology, tissue engineering, and regenerative medicine, contributing to advancements in understanding and treating conditions related to collagen dysfunction.
Antibody Name:
COL13A1 Antibody (PACO07451)
Antibody SKU:
PACO07451
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000-1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from human COL13A1. at AA range: 41-90
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of 1,Hela 2,Mouse-kidney cells using primary antibody diluted at 1:2000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour).
Synonyms:
Collagen α-1(XIII) chain (COLXIIIA1)
UniProt Protein Function:
COL13A1: Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. 10 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 10q22Cellular Component: collagen type XIII; endoplasmic reticulum lumen; extracellular region; intercellular junction; plasma membraneMolecular Function: heparin binding; protein bindingBiological Process: cell differentiation; cell-cell adhesion; cell-matrix adhesion; collagen catabolic process; endochondral ossification; extracellular matrix disassembly; extracellular matrix organization and biogenesis; morphogenesis of a branching structure
UniProt Protein Details:
NCBI Summary:
This gene encodes the alpha chain of one of the nonfibrillar collagens. The function of this gene product is not known, however, it has been detected at low levels in all connective tissue-producing cells so it may serve a general function in connective tissues. Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, collagen XIII is a trimer; it is not known whether this trimer is composed of one or more than one alpha chain isomer. A number of alternatively spliced transcript variants have been described, but the full length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
