The Colipase Polyclonal Antibody (CAB6364) is a vital tool for researchers studying colipase, a protein that plays a crucial role in lipid digestion and absorption in the digestive system. This antibody is produced in rabbits and demonstrates high reactivity with samples from various species, making it suitable for use in immunohistochemistry and ELISA applications. By binding specifically to colipase, this antibody enables the visualization and analysis of colipase expression in different tissues and cell types.Colipase is an essential cofactor for pancreatic lipase, aiding in the breakdown of dietary fats for absorption in the intestines.
Dysregulation of colipase function has been linked to disorders such as pancreatic insufficiency and malabsorption syndromes. Research on colipase may provide insights into these conditions and lead to the development of therapeutic interventions targeting lipid metabolism. Overall, the Colipase Polyclonal Antibody is a valuable tool for investigating the role of colipase in health and disease.
Product Name:
CLPS Rabbit Polyclonal Antibody
SKU:
CAB6364
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-112 of human CLPS (NP_001823.1).
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1208
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse pancreas, using CLPS antibody (CAB6364) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
