Description
CSGALNACT2 Antibody (PACO15719)
The CSGALNACT2 Polyclonal Antibody (PAC015719) is a valuable tool for research involving CSGALNACT2, an enzyme involved in the biosynthesis of glycosaminoglycans (GAGs) that are important for cell signaling and extracellular matrix structure. This antibody is produced in rabbits and has high reactivity with human samples, making it ideal for Western blot applications. CSGALNACT2 plays a crucial role in the modification of proteoglycans, which are involved in various cellular processes such as cell adhesion, growth factor binding, and signaling.
Dysregulation of CSGALNACT2 has been implicated in diseases like cancer and musculoskeletal disorders. By using this antibody to detect CSGALNACT2, researchers can better understand its function and potentially develop targeted therapies for associated conditions. Overall, the CSGALNACT2 Polyclonal Antibody is a valuable tool for studying the role of CSGALNACT2 in health and disease, with potential applications in research areas such as oncology, musculoskeletal biology, and developmental biology.
| Antibody Name: | CSGALNACT2 Antibody (PACO15719) |
| Antibody SKU: | PACO15719 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human CSGALNACT2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15719(CSGALNACT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15719(CSGALNACT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on chromosome X. Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid, (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. |
| Synonyms: | chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| UniProt Protein Function: | GALNACT2: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.4.1.174 Chromosomal Location of Human Ortholog: 10q11.21 Cellular Component: Golgi membrane; membrane; integral to Golgi membrane Molecular Function:acetylgalactosaminyltransferase activity; metal ion binding; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Biological Process: chondroitin sulfate metabolic process; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; proteoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; pathogenesis; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process |
| NCBI Summary: | This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q8N6G5 |
| NCBI GenInfo Identifier: | 60391915 |
| NCBI Gene ID: | 55454 |
| NCBI Accession: | Q8N6G5.1 |
| UniProt Secondary Accession: | Q8N6G5,Q6MZJ5, Q6MZP6, Q8TCH4, Q9P1I6, B3KWL7, |
| UniProt Related Accession: | Q8N6G5 |
| Molecular Weight: | 38,440 Da |
| NCBI Full Name: | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| NCBI Synonym Full Names: | chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| NCBI Official Symbol: | CSGALNACT2Â Â |
| NCBI Official Synonym Symbols: | CHGN2; PRO0082; GALNACT2; GALNACT-2Â Â |
| NCBI Protein Information: | chondroitin sulfate N-acetylgalactosaminyltransferase 2; beta 4 GalNAcT-2; chondroitin beta1,4 N-acetylgalactosaminyltransferase 2 |
| UniProt Protein Name: | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| UniProt Synonym Protein Names: | Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; Beta4GalNAcT-2; GalNAcT-2 |
| Protein Family: | Chondroitin sulfate N-acetylgalactosaminyltransferase |
| UniProt Gene Name: | CSGALNACT2Â Â |
| UniProt Entry Name: | CGAT2_HUMAN |
