The CXXC5 Polyclonal Antibody (PAC036738) is a crucial tool for researchers studying the CXXC5 protein, which plays a key role in epigenetic regulation and gene expression. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for various research applications, such as Western blotting and immunohistochemistry.CXXC5 is a transcriptional regulator that interacts with DNA methyltransferases and histone-modifying enzymes, influencing chromatin structure and gene transcription. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions.
By targeting CXXC5 with this antibody, researchers can better understand its function and potential as a therapeutic target in these disease contexts.Overall, the CXXC5 Polyclonal Antibody is a valuable tool for investigating the role of CXXC5 in epigenetic regulation and gene expression, providing insights into its potential implications for disease pathogenesis and therapeutic interventions.
Antibody Name:
CXXC5 Antibody (PACO36738)
Antibody SKU:
PACO36738
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human CXXC-type zinc finger protein 5 protein (1-227AA)
Immunohistochemistry of paraffin-embedded human brain tissue using PACO36738 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO36738 at dilution of 1:100.
Background:
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ.
Synonyms:
CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF), CXXC5
UniProt Protein Function:
CXXC5: May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding; sequence-specific DNA binding; signal transducer activity; transcription factor bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
