Anti-CXXC5 Antibody (PACO16093)

Antibody Name:	CXXC5 Antibody (PACO16093)
Antibody SKU:	PACO16093
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human CXXC5

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16093(CXXC5 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16093(CXXC5 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).

Background:

CXXC5 (CXXC finger 5), also known as RINF or HSPC195, is a 322 amino acid, protein that localizes to both the nucleus and the cytoplasm and contains one CXXC-type zinc finger. Interacting with Dvl-1, CXXC5 acts as a mediator of Wnt signaling in neural stem cells and is thought to participate in the activation of MAP kinase pathways. The gene encoding CXXC5 maps to human chromosome 5 and is expressed as multiple alternatively spliced isoforms.

Synonyms:

CXXC finger protein 5

UniProt Protein Function:	CXXC5: May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding; sequence-specific DNA binding; signal transducer activity; transcription factor bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Code:	Q7LFL8
NCBI GenInfo Identifier:	167011303
NCBI Gene ID:	51523
NCBI Accession:	Q7LFL8.1
UniProt Secondary Accession:	Q7LFL8,Q8TB79, Q9NV51, Q9P0S8, B3KND0, C8CBA8
UniProt Related Accession:	Q7LFL8
Molecular Weight:	24,072 Da
NCBI Full Name:	CXXC-type zinc finger protein 5
NCBI Synonym Full Names:	CXXC finger protein 5
NCBI Official Symbol:	CXXC5
NCBI Official Synonym Symbols:	CF5; WID; RINF; HSPC195
NCBI Protein Information:	CXXC-type zinc finger protein 5
UniProt Protein Name:	CXXC-type zinc finger protein 5
UniProt Synonym Protein Names:	Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; Retinoid-inducible nuclear factor; RINF
Protein Family:	CXXC-type zinc finger protein
UniProt Gene Name:	CXXC5
UniProt Entry Name:	CXXC5_HUMAN

ELISA Kits

Human CXXC5 (CXXC-Type Zinc Finger Protein 5) ELISA Kit (HUFI03403)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)