The CXXC5 Polyclonal Antibody (PAC016093) is a valuable tool for researchers studying CXXC5, a protein involved in epigenetic regulation and gene expression. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting CXXC5 in human samples, making it suitable for a variety of research applications, including Western blotting.CXXC5 plays a crucial role in controlling gene transcription by interacting with DNA methylation and histone modification pathways. Its dysregulation has been linked to various diseases, including cancer and developmental disorders.
By targeting CXXC5, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.With its ability to detect CXXC5 in diverse cell types and tissues, the CXXC5 Polyclonal Antibody is a valuable tool for advancing our understanding of epigenetic regulation and its impact on human health. Researchers in the fields of genetics, oncology, and developmental biology will find this antibody indispensable for their studies.
Antibody Name:
CXXC5 Antibody (PACO16093)
Antibody SKU:
PACO16093
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human CXXC5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16093(CXXC5 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16093(CXXC5 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
CXXC5 (CXXC finger 5), also known as RINF or HSPC195, is a 322 amino acid, protein that localizes to both the nucleus and the cytoplasm and contains one CXXC-type zinc finger. Interacting with Dvl-1, CXXC5 acts as a mediator of Wnt signaling in neural stem cells and is thought to participate in the activation of MAP kinase pathways. The gene encoding CXXC5 maps to human chromosome 5 and is expressed as multiple alternatively spliced isoforms.
Synonyms:
CXXC finger protein 5
UniProt Protein Function:
CXXC5: May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding; sequence-specific DNA binding; signal transducer activity; transcription factor bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
