The DAB2 Polyclonal Antibody is specifically designed for research involving DAB2, a protein involved in cell signaling pathways and tumor suppression. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It binds to the DAB2 protein, allowing for precise detection and analysis in a variety of cell types, making it ideal for studies in cancer research, cell biology, and signal transduction mechanisms.DAB2, also known as Disabled homolog 2, is a key player in regulating cell growth, differentiation, and migration.
Its role as a tumor suppressor makes it a promising target for studying cancer progression and metastasis. Understanding the function of DAB2 could lead to innovative therapies for treating cancer and other related diseases. Researchers interested in unraveling the complexities of cell signaling pathways and tumor development will find the DAB2 Polyclonal Antibody essential for their studies.
Product Name:
DAB2 Polyclonal Antibody
SKU:
CAB3822
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 340-580 of human DAB2 (NP_001334.2).
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1601
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using DAB2 Rabbit pAb (CAB3822) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
