The DGKK Polyclonal Antibody (PAC023254) is specifically designed for research involving DGKK, a protein kinase implicated in various cellular processes. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot assays. By binding to DGKK, the antibody enables precise detection and analysis of the protein in multiple cell types, making it ideal for investigations in molecular biology and cell signaling pathways.DGKK, also known as diacylglycerol kinase kappa, plays a crucial role in lipid metabolism and cell signaling, making it a key player in regulating cellular functions such as proliferation and differentiation.
Understanding the function and regulation of DGKK is essential for unraveling its significance in diseases like cancer, metabolic disorders, and neurological conditions. By targeting DGKK, researchers aim to uncover potential therapeutic strategies that manipulate cellular processes for disease intervention and treatment.
DGKK: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Belongs to the eukaryotic diacylglycerol kinase family.Protein type: EC 2.7.1.107; Kinase, lipidChromosomal Location of Human Ortholog: Xp11.22Cellular Component: cytoplasm; plasma membraneMolecular Function: ATP binding; diacylglycerol kinase activity; metal ion bindingBiological Process: blood coagulation; diacylglycerol metabolic process; phosphorylation; platelet activation; protein kinase C activation; response to oxidative stress
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
