The DMRT1 Antibody (CAB8411) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to DMRT1 and has been validated for use in applications such as Western blotting.DMRT1 is a transcription factor that is involved in the development of male sex organs and the maintenance of male characteristics in various species. Mutations in this gene have been linked to disorders of sexual development and infertility in humans and other animals. By using the DMRT1 Polyclonal Antibody, researchers can accurately detect and analyze DMRT1 expression in different tissues and cell types, providing insights into its function and potential therapeutic implications.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
DMRT1 Antibody
SKU:
CAB8411
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
DMT1, CT154, DMRT1
Positive Sample:
U-937
Cellular Localization:
Nucleus.
Calculated MW:
39kDa
Observed MW:
39kDa
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
Purification Method
Affinity purification
Gene ID
1761
RRID
AB_2769186
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using DMRT1 Rabbit pAb (CAB8411) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
