The Anti-DNA2 Antibody (CAB9354) is a high-quality tool designed for research involving DNA2, an essential DNA replication and repair enzyme. This polyclonal antibody, raised in rabbits, is highly specific for human samples and has been validated for use in a variety of applications including Western blot and immunofluorescence.DNA2 plays a crucial role in maintaining genomic stability by participating in various DNA metabolic pathways, such as DNA replication, recombination, and repair. Dysregulation of DNA2 function has been linked to genomic instability, cancer development, and neurodegenerative diseases. By targeting the DNA2 protein, researchers can investigate its role in DNA maintenance and repair processes, providing insights into disease mechanisms and potential therapeutic targets.
With its high reactivity and specificity, the Anti-DNA2 Antibody is an invaluable tool for studies in molecular biology, genetics, and cancer research. Its ability to detect and quantify DNA2 protein levels in different cell types makes it an essential reagent for understanding the molecular mechanisms underlying DNA repair and replication pathways. Invest in the Anti-DNA2 Antibody (CAB9354) for precise and reliable results in your research endeavors.
Product Name:
DNA2 Polyclonal Antibody
SKU:
CAB9354
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 811-1060 of human DNA2 (NP_001073918.2).
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1763
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using DNA2 Rabbit pAb (CAB9354) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 120s.
