The DOK6 Polyclonal Antibody (PACO23256) is a valuable tool for researchers studying the role of DOK6 in cellular signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting. By targeting the DOK6 protein, researchers can investigate its function in diverse cell types, opening up new possibilities for research in cell signaling and disease pathways.DOK6, a member of the downstream of tyrosine kinase (DOK) family, is involved in regulating signal transduction pathways in response to various stimuli.
Understanding its role in cell signaling can shed light on its potential implications in diseases such as cancer, diabetes, and neurological disorders. The DOK6 Polyclonal Antibody provides a reliable tool for researchers looking to explore the functions and interactions of DOK6 in different cellular contexts, offering new insights into its potential therapeutic applications.
Synthesized peptide derived from internal of human DOK6.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using DOK6 antibody.
Immunofluorescence analysis of A549 cells, using DOK6 antibody.
Background:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
Synonyms:
Downstream of tyrosine kinase 6; Docking protein 6; DOK6; DOK5L;
UniProt Protein Function:
DOK6: ocking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Interacts via its PTB domain with phosphorylated Ret, promoting neurite growth. May have a role in brain development and/or maintenance. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
UniProt Protein Details:
Protein type:Adaptor/scaffold
Chromosomal Location of Human Ortholog: 18q22.2
Molecular Function:insulin receptor binding; protein binding
NCBI Summary:
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
