The Dynactin Subunit 2 Polyclonal Antibody (CAB2200) is a valuable tool for researchers studying the role of Dynactin Subunit 2 in various cellular processes. This antibody, raised in rabbits, is highly specific and reacts with human samples, making it ideal for Western blot applications. By binding to Dynactin Subunit 2, the antibody enables accurate detection and analysis of this protein in different cell types.Dynactin Subunit 2 is a critical component of the dynactin complex, which is involved in intracellular transport and cellular organization. Research has shown that abnormalities in Dynactin Subunit 2 can lead to defects in cell division, motility, and signaling, making it an important target for studying various diseases and biological processes.
By using the Dynactin Subunit 2 Polyclonal Antibody, researchers can gain insight into the functions and regulation of Dynactin Subunit 2, paving the way for advancements in cell biology, neurology, and developmental biology. This antibody is a valuable tool for those investigating the molecular mechanisms underlying cellular processes and diseases related to Dynactin Subunit 2 dysfunction.
Product Name:
DCTN2 Rabbit Polyclonal Antibody
SKU:
CAB2200
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-320 of human DCTN2 (NP_006391.1).
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10540
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of MCF-7 cells, using DCTN2 antibody (CAB2200) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
