Description
EDNRA Antibody (PACO17819)
The EDNRA Polyclonal Antibody (PAC017819) is a valuable tool for researchers studying the Endothelin A Receptor (EDNRA) protein, which is involved in various physiological processes such as vasoconstriction, cell proliferation, and tissue remodeling. This antibody, produced in rabbits, is highly specific for detecting EDNRA in human samples and is validated for use in Western blot applications.The EDNRA receptor plays an essential role in the cardiovascular system and has been implicated in various diseases, including hypertension, heart failure, and cancer.
Understanding the function and regulation of EDNRA is crucial for developing targeted therapies and treatments for these conditions. With its high reactivity and specificity, the EDNRA Polyclonal Antibody is an ideal tool for studying EDNRA expression and activity in different cell types, making it a valuable asset for cardiovascular and cancer research.
| Antibody Name: | EDNRA Antibody (PACO17819) |
| Antibody SKU: | PACO17819 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human EDNRA |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17819(EDNRA Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cells, Primary antibody: PACO17819(EDNRA Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17819(EDNRA Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. |
| Synonyms: | endothelin receptor type A |
| UniProt Protein Function: | EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q31.22 Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; lipid raft Molecular Function:endothelin receptor activity; protein binding; phosphoinositide phospholipase C activity Biological Process: positive regulation of odontogenesis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neural crest cell development; metabolic process; heart development; smooth muscle cell proliferation; response to morphine; response to lipopolysaccharide; glucose transport; sensory perception of pain; signal transduction; enteric nervous system development; Rho protein signal transduction; regulation of epithelial cell proliferation; histamine secretion; elevation of cytosolic calcium ion concentration; negative regulation of cAMP biosynthetic process; smooth muscle contraction; fibroblast proliferation; regulation of blood pressure; protein kinase C activation; positive regulation of cell proliferation; artery smooth muscle contraction; aging; penile erection; vasoconstriction; in utero embryonic development; glomerular filtration; adenylate cyclase activation; respiratory gaseous exchange; patterning of blood vessels; cell proliferation; G-protein coupled receptor protein signaling pathway; phospholipase C activation; maternal process involved in parturition; response to hypoxia; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of apoptosis; positive regulation of inflammatory response Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P25101 |
| NCBI GenInfo Identifier: | 119606 |
| NCBI Gene ID: | 1909 |
| NCBI Accession: | P25101.1 |
| UniProt Secondary Accession: | P25101,O43441, Q16432, Q16433, Q8TBH2, B2R723, B4E2V6 B7Z9G6, D3DP03, E7ER36, |
| UniProt Related Accession: | P25101,AAB24923 |
| Molecular Weight: | 23,803 Da |
| NCBI Full Name: | Endothelin-1 receptor |
| NCBI Synonym Full Names: | endothelin receptor type A |
| NCBI Official Symbol: | EDNRAÂ Â |
| NCBI Official Synonym Symbols: | ETA; ET-A; ETAR; ETRA; ETA-R; hET-ARÂ Â |
| NCBI Protein Information: | endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor |
| UniProt Protein Name: | Endothelin-1 receptor |
| UniProt Synonym Protein Names: | Endothelin A receptor; ET-A; ETA-R; hET-AR |
| Protein Family: | Endothelin-1 receptor |
| UniProt Gene Name: | EDNRAÂ Â |
| UniProt Entry Name: | EDNRA_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
