Description
EFNB1/EFNB2 Antibody (PACO06468)
The EFNB1/EFNB2 Polyclonal Antibody (PACO06468) is a valuable tool for researchers studying Ephrin-B proteins, specifically Ephrin-B1 and Ephrin-B2, which play important roles in cell signaling and development. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to Ephrin-B1 and Ephrin-B2 proteins, this antibody enables detection and analysis in a variety of cell types, making it ideal for studies in developmental biology, neuroscience, and cancer research.
Ephrin-B proteins are known for their involvement in axon guidance, synaptic plasticity, and cell migration during embryonic development and beyond. Dysregulation of Ephrin-B signaling has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular conditions. The EFNB1/EFNB2 Polyclonal Antibody offers researchers a reliable tool to investigate the roles of these proteins in different cellular processes, potentially leading to new insights and therapeutic strategies.
| Antibody Name: | EFNB1/EFNB2 Antibody (PACO06468) |
| Antibody SKU: | PACO06468 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human Ephrin-B1/2 around the non-phosphorylation site of Y330. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of HELA 293T cells using Ephrin-B1/2 Polyclonal Antibody. |
 | Western Blot analysis of 293 cells using Ephrin-B1/2 Polyclonal Antibody. |
| Synonyms: | EFNB1; EFL3; EPLG2; LERK2; Ephrin-B1; EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; EFNB2; EPLG5; HTKL; LERK5; Ephrin-B2; EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L |
| UniProt Protein Function: | EFNB1: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Ligand, receptor tyrosine kinase Chromosomal Location of Human Ortholog: Xq12 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; synapse; nucleus; lipid raft Molecular Function:protein binding; ephrin receptor binding Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway; positive regulation of T cell proliferation; cell adhesion; embryonic pattern specification; neural crest cell migration Disease: Craniofrontonasal Syndrome |
| NCBI Summary: | The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P98172 |
| NCBI GenInfo Identifier: | 1706668 |
| NCBI Gene ID: | 1947 |
| NCBI Accession: | P98172.1 |
| UniProt Secondary Accession: | P98172,D3DVU0, |
| UniProt Related Accession: | P98172 |
| Molecular Weight: | 346 |
| NCBI Full Name: | Ephrin-B1 |
| NCBI Synonym Full Names: | ephrin-B1 |
| NCBI Official Symbol: | EFNB1Â Â |
| NCBI Official Synonym Symbols: | CFND; CFNS; EFB1; EFL3; EPLG2; Elk-L; LERK2Â Â |
| NCBI Protein Information: | ephrin-B1; EFL-3; LERK-2; ELK ligand; ligand of eph-related kinase 2; eph-related receptor tyrosine kinase ligand 2 |
| UniProt Protein Name: | Ephrin-B1 |
| UniProt Synonym Protein Names: | EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2 |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNB1Â Â |
| UniProt Entry Name: | EFNB1_HUMAN |
| Antibodies | ELISA Kits |
| Phospho-EFNB1/EFNB2 (Y330) Antibody (PACO00276) | Ephrin B1/B2 (Phospho-Tyr330) Colorimetric Cell-Based ELISA Kit |
| Phospho-EFNB1/EFNB2 (Y329) Antibody (PACO03584) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
