The ELAVL2/ELAVL4 Polyclonal Antibody (PAC023213) is a valuable tool for researchers studying ELAVL2 and ELAVL4, two RNA-binding proteins that play essential roles in post-transcriptional gene regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting these proteins in human samples, making it ideal for Western blot applications.ELAVL2 and ELAVL4 are key players in regulating mRNA stability and translation, impacting processes such as cell proliferation, differentiation, and apoptosis.
Dysregulation of these proteins has been linked to various diseases, including cancer and neurological disorders, highlighting their importance in pathophysiology.By using the ELAVL2/ELAVL4 Polyclonal Antibody, researchers can gain valuable insights into the function and expression of these critical RNA-binding proteins. This antibody enables accurate detection and analysis, facilitating detailed investigations into the roles of ELAVL2 and ELAVL4 in cellular processes and disease mechanisms.
ELAVL2: Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:RNA-binding
Chromosomal Location of Human Ortholog: 9p21.3
Cellular Component: nucleoplasm
Molecular Function:mRNA 3'-UTR binding; protein binding; RNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent
NCBI Summary:
The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
