Description
ELK3 Antibody (PACO03611)
The ELK3 Polyclonal Antibody (PACO03611) is a vital tool for researchers studying the ELK3 protein, a transcription factor involved in cell growth and differentiation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ELK3 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an essential tool for studies in cancer biology and molecular biology research.ELK3, also known as ETS domain-containing protein Elk-3, plays a crucial role in regulating gene expression in response to various stimuli, including growth factors and cytokines. Its involvement in cell proliferation and differentiation makes it a promising target for research on cancer development, metastasis, and progression.
By understanding the function and regulation of ELK3, researchers can gain valuable insights into the mechanisms underlying these processes, ultimately leading to the development of targeted therapies for cancer treatment.Overall, the ELK3 Polyclonal Antibody is a valuable asset for researchers looking to explore the role of ELK3 in cellular processes and disease pathogenesis. Its specificity, sensitivity, and reliability make it a dependable tool for unraveling the complexities of ELK3 signaling pathways and identifying potential therapeutic targets for cancer and other diseases.
| Antibody Name: | ELK3 Antibody |
| Antibody SKU: | PACO03611 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from human Net around the non-phosphorylation site of S357. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ELK3; NET; SAP2; ETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET; Serum response factor accessory protein 2; SAP-2; SRF accessory protein 2 |
| UniProt Protein Function: | ELK3: a transcription factor of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. May be a negative regulator of transcription but can activate transcription when co expressed with Ras, Src or Mos. Activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q23 Cellular Component: intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus Molecular Function:protein binding; purine-rich negative regulatory element binding; transcription corepressor activity Biological Process: cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; signal transduction |
| NCBI Summary: | This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P41970 |
| NCBI GenInfo Identifier: | 116241349 |
| NCBI Gene ID: | 2004 |
| NCBI Accession: | P41970.2 |
| UniProt Secondary Accession: | P41970,Q6FG57, Q6GU29, Q9UD17, B2R6S6, |
| UniProt Related Accession: | P41970,AAB34628 |
| Molecular Weight: | 44,240 Da |
| NCBI Full Name: | ETS domain-containing protein Elk-3 |
| NCBI Synonym Full Names: | ELK3, ETS transcription factor |
| NCBI Official Symbol: | ELK3Â Â |
| NCBI Official Synonym Symbols: | ERP; NET; SAP2; SAP-2Â Â |
| NCBI Protein Information: | ETS domain-containing protein Elk-3 |
| UniProt Protein Name: | ETS domain-containing protein Elk-3 |
| UniProt Synonym Protein Names: | ETS-related protein ERP; ETS-related protein NET; Serum response factor accessory protein 2; SAP-2; SRF accessory protein 2 |
| Protein Family: | ETS domain-containing protein |
| UniProt Gene Name: | ELK3Â Â |
| UniProt Entry Name: | ELK3_HUMAN |
