The ELN Polyclonal Antibody (CAB12433) is a valuable tool for research involving ELN, a key protein involved in the structure and function of elastic fibers in connective tissues. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in various applications, including Western blotting.ELN, also known as elastin, plays a critical role in providing elasticity and resilience to tissues such as skin, lungs, and blood vessels. Mutations or dysregulation of ELN have been implicated in various diseases, including cardiovascular disorders, connective tissue disorders, and age-related conditions.
Research on ELN is important for understanding the mechanisms underlying these diseases and for exploring potential therapeutic strategies.By targeting ELN, researchers can investigate the function and regulation of elastic fibers in different tissues, leading to insights that may help in the development of new treatments and interventions. The ELN Polyclonal Antibody enables precise detection and analysis of ELN in various experimental settings, making it an essential tool for studies in physiology, pathology, and drug development.
Product Name:
ELN Rabbit Polyclonal Antibody
SKU:
CAB12433
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human ELN (P15502).
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa.
Purification Method:
Affinity purification
Gene ID:
2006
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human liver cancer using ELN Rabbit pAb (CAB12433) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
