Description
| Product Name: | Eotaxin-1 monoclonal antibody |
| Product Code: | AGIM0014 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | hEOT1 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Storage conditions:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P51671 |
| Background: | Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN- ?? timulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions. |
| UniProt Protein Function: | CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular region; extracellular space; intracellular Molecular Function:CCR chemokine receptor binding; chemokine activity; protein binding Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To |
| NCBI Summary: | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P51671 |
| NCBI GenInfo Identifier: | 1706661 |
| NCBI Gene ID: | 6356 |
| NCBI Accession: | P51671.1 |
| UniProt Secondary Accession: | P51671,P50877, Q92490, Q92491, |
| UniProt Related Accession: | P51671 |
| Molecular Weight: | 10,732 Da |
| NCBI Full Name: | Eotaxin |
| NCBI Synonym Full Names: | C-C motif chemokine ligand 11 |
| NCBI Official Symbol: | CCL11Â Â |
| NCBI Official Synonym Symbols: | SCYA11Â Â |
| NCBI Protein Information: | eotaxin |
| UniProt Protein Name: | Eotaxin |
| UniProt Synonym Protein Names: | C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11 |
| Protein Family: | Eotaxin |
| UniProt Gene Name: | CCL11Â Â |
| UniProt Entry Name: | CCL11_HUMAN |
