Description
ERG Antibody (CAB1240)
The ERG Antibody (CAB1240) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot analysis.ERG is known for its role in modulating gene expression and has been implicated in the development of certain cancers, particularly prostate cancer. By targeting the ERG protein, researchers can gain insights into its function and potential as a therapeutic target for cancer treatment.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | ERG Antibody |
| SKU: | CAB1240 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | MAST IKEA LSVV SEDQ SLFE CAYG TPHL AKTE MTAS SSSD YGQT SKMS PRVP QQDW LSQP PARV TIKM ECNP SQVN GSRN SPDE CSVA KGGK MVGS PDTV GMNY GSYM EEKH MPPP NMTT NERR VIVP ADPT LWST DHVR QWLE WAVK EYGL PDVN ILLF QNID GKEL CKMT KDDF QRLT PSYN ADIL LSHL HYLR ETPL PHLT SDDV DKAL QNSP RLMH ARNT GGAA FIFP NTSV YPEA TQRI TTRP DLPY EPPR RSAW TGHG HPTP QSKA AQPS PSTV | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | p55, erg-3, ERG |
| Positive Sample: | MCF7, THP-1, HeLa, BT-474, 293T |
| Cellular Localization: | Cytoplasm, Nucleus. |
| Calculated MW: | 54kDa |
| Observed MW: | 60kDa |
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.
| Purification Method | Affinity purification |
| Gene ID | 2078 |
| RRID | AB_2759244 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using ERG Rabbit pAb (CAB1240) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
