The FAR2 Polyclonal Antibody (PACO38174) is a valuable tool for researchers studying FAR2, a key enzyme involved in fatty acid metabolism and lipid biosynthesis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the FAR2 protein, this antibody enables the detection and analysis of FAR2 in various cell types, making it well-suited for studies in metabolism, lipid signaling, and cellular bioenergetics.
FAR2, also known as fatty acyl-coA reductase 2, plays a crucial role in lipid metabolism by catalyzing the conversion of fatty acyl-CoA to fatty alcohols. Dysregulation of FAR2 activity has been implicated in various metabolic disorders, making it a promising target for research into obesity, diabetes, and cardiovascular disease. Understanding the role of FAR2 in lipid homeostasis may provide insights into the development of therapeutic interventions for these conditions.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO38174 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO38174 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO38174 at dilution of 1:100.
Background:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.
MLSTD1: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. Belongs to the fatty acyl-CoA reductase family.Protein type: Oxidoreductase; Membrane protein, integral; EC 1.2.1.n2; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12p11.22Cellular Component: peroxisomal membrane; peroxisomal matrix; endoplasmic reticulum membrane; integral to membrane; peroxisomeMolecular Function: long-chain-fatty-acyl-CoA reductase activityBiological Process: cellular lipid metabolic process; ether lipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
