The FBXL18 Polyclonal Antibody (PAC02697) is a valuable tool for researchers studying FBXL18, a protein involved in cell cycle regulation and protein degradation pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications.FBXL18 is a member of the F-box protein family, which is known to play a role in targeting proteins for ubiquitination and degradation by the proteasome. By targeting specific substrates for degradation, FBXL18 is involved in regulating important cellular processes such as cell division, DNA replication, and gene expression.
Researchers in the fields of cell biology, cancer research, and drug development will find the FBXL18 Polyclonal Antibody to be a valuable tool for detecting and studying FBXL18 protein levels and activity in various cell types. By understanding the function of FBXL18, researchers can gain insights into its role in disease processes and potentially identify new therapeutic targets for various disorders.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO26697 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO26697 at dilution of 1:100 and Cy3-congugated Goat Anti-Rabbit IgG.
Immunohistochemistry of paraffin-embedded human lymphoid tissue using PACO26697 at dilution of 1:100.
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
Synonyms:
F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18), FBXL18, FBL18
UniProt Protein Function:
FBXL18: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7p22.1Cellular Component: cytosolMolecular Function: ubiquitin-protein ligase activityBiological Process: post-translational protein modification; protein polyubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
