Description
FLRT3 Antibody (PACO47150)
The FLRT3 Polyclonal Antibody (PAC047150) is a valuable tool for researchers studying FLRT3, a crucial protein involved in neural development and synapse formation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications.FLRT3, also known as fibronectin leucine-rich transmembrane protein 3, plays a significant role in axon guidance and neural circuit formation during development. Its interaction with other proteins involved in synaptic signaling suggests its importance in neuronal connectivity and plasticity.
By targeting FLRT3, researchers can gain insight into the mechanisms underlying brain development and function.The FLRT3 Polyclonal Antibody enables the detection and analysis of FLRT3 in various cell types, making it an essential tool for studies in neuroscience, developmental biology, and neurodegenerative disorders. Understanding the functions of FLRT3 could lead to advancements in treatments for neurological conditions and enhance our knowledge of brain development.
| Antibody Name: | FLRT3 Antibody (PACO47150) |
| Antibody SKU: | PACO47150 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Leucine-rich repeat transmembrane protein FLRT3 protein (209-264AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: DARS2 antibody at 16µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse liver tissue. Lane 3: Mouse brain tissue. Lane 4: Mouse skeletal muscle tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 73 kDa. Observed band size: 73 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO47150 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity). |
| Synonyms: | Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3), FLRT3, KIAA1469 |
| UniProt Protein Function: | FLRT3: May have a function in cell adhesion and/or receptor signaling. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 20p11 Cellular Component: cytoplasm; integral to plasma membrane; nerve terminal; plasma membrane Molecular Function:protein binding; protein homodimerization activity; protein kinase inhibitor activity Biological Process: cytokine and chemokine mediated signaling pathway; embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; heart development; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; neurite development; response to axon injury; synaptogenesis Disease: Hypogonadotropic Hypogonadism 21 With Or Without Anosmia |
| UniProt Code: | Q9NZU0 |
| NCBI GenInfo Identifier: | 7019383 |
| NCBI Gene ID: | 23767 |
| NCBI Accession: | NP_037413.1 |
| UniProt Secondary Accession: | Q9NZU0,Q542Z9, Q96K39, Q96K42, Q96KB1, Q9P259, D3DW20 |
| UniProt Related Accession: | Q9NZU0 |
| Molecular Weight: | 73,004 Da |
| NCBI Full Name: | leucine-rich repeat transmembrane protein FLRT3 |
| NCBI Synonym Full Names: | fibronectin leucine rich transmembrane protein 3 |
| NCBI Official Symbol: | FLRT3Â Â |
| NCBI Official Synonym Symbols: | HH21Â Â |
| NCBI Protein Information: | leucine-rich repeat transmembrane protein FLRT3 |
| UniProt Protein Name: | Leucine-rich repeat transmembrane protein FLRT3 |
| UniProt Synonym Protein Names: | Fibronectin-like domain-containing leucine-rich transmembrane protein 3 |
| Protein Family: | Leucine-rich repeat transmembrane protein |
| UniProt Gene Name: | FLRT3Â Â |
| UniProt Entry Name: | FLRT3_HUMAN |
