Description
FLT3LG Antibody (PACO02184)
The FLT3LG Monoclonal Antibody (PACO02184) is a valuable tool for researchers studying FLT3 ligand, a cytokine that plays a key role in the development and function of immune cells. This antibody, generated in mice, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.FLT3 ligand is known to promote the proliferation and differentiation of hematopoietic stem cells, leading to the generation of various immune cell types. It is involved in immune response regulation and has been implicated in conditions such as leukemia and immune deficiencies.
The FLT3LG Monoclonal Antibody binds specifically to FLT3 ligand, allowing for precise detection and analysis of this important cytokine in biological samples.Researchers in the fields of immunology, hematology, and cancer biology will find this antibody essential for investigating the role of FLT3 ligand in immune system development and function. By targeting FLT3 ligand with this antibody, researchers can gain insights into potential therapeutic strategies for diseases related to immune cell dysfunction.
| Antibody Name: | FLT3LG Antibody |
| Antibody SKU: | PACO02184 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the C-terminal region of human Flt3-L. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | FLT3LG; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine |
| UniProt Protein Function: | FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: extracellular space; membrane; integral to membrane Molecular Function:protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding; receptor binding Biological Process: regulation of myeloid dendritic cell activation; positive regulation of natural killer cell differentiation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; signal transduction; positive regulation of myoblast differentiation |
| NCBI Summary: | Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | P49771 |
| NCBI GenInfo Identifier: | 1706818 |
| NCBI Gene ID: | 2323 |
| NCBI Accession: | P49771.1 |
| UniProt Secondary Accession: | P49771,Q05C96, A0AVC2, B9EGH2, |
| UniProt Related Accession: | P49771 |
| Molecular Weight: | approximately 150 kDa |
| NCBI Full Name: | Fms-related tyrosine kinase 3 ligand |
| NCBI Synonym Full Names: | fms-related tyrosine kinase 3 ligand |
| NCBI Official Symbol: | FLT3LGÂ Â |
| NCBI Official Synonym Symbols: | FL; FLT3LÂ Â |
| NCBI Protein Information: | fms-related tyrosine kinase 3 ligand; flt3 ligand |
| UniProt Protein Name: | Fms-related tyrosine kinase 3 ligand |
| UniProt Synonym Protein Names: | SL cytokine |
| Protein Family: | Receptor-type tyrosine-protein kinase |
| UniProt Gene Name: | FLT3LGÂ Â |
| UniProt Entry Name: | FLT3L_HUMAN |
