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FLT3LG Antibody (PACO02184)

SKU:
PACO02184
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Antibody Name:FLT3LG Antibody
Antibody SKU:PACO02184
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the C-terminal region of human Flt3-L.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:FLT3LG; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine
UniProt Protein Function:FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: extracellular space; membrane; integral to membrane

Molecular Function:protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding; receptor binding

Biological Process: regulation of myeloid dendritic cell activation; positive regulation of natural killer cell differentiation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; signal transduction; positive regulation of myoblast differentiation

NCBI Summary:Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
UniProt Code:P49771
NCBI GenInfo Identifier:1706818
NCBI Gene ID:2323
NCBI Accession:P49771.1
UniProt Secondary Accession:P49771,Q05C96, A0AVC2, B9EGH2,
UniProt Related Accession:P49771
Molecular Weight:approximately 150 kDa
NCBI Full Name:Fms-related tyrosine kinase 3 ligand
NCBI Synonym Full Names:fms-related tyrosine kinase 3 ligand
NCBI Official Symbol:FLT3LG  
NCBI Official Synonym Symbols:FL; FLT3L  
NCBI Protein Information:fms-related tyrosine kinase 3 ligand; flt3 ligand
UniProt Protein Name:Fms-related tyrosine kinase 3 ligand
UniProt Synonym Protein Names:SL cytokine
Protein Family:Receptor-type tyrosine-protein kinase
UniProt Gene Name:FLT3LG  
UniProt Entry Name:FLT3L_HUMAN

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