The FOXB1/FOXB2 Antibody (PAC021934) is a high-quality antibody designed for research involving FOXB1 and FOXB2 proteins, transcription factors known to play key roles in developmental processes and tumorigenesis. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications including Western blotting and immunohistochemistry.FOXB1 and FOXB2 are members of the FOX family of transcription factors, involved in regulating gene expression and cell differentiation. Dysregulation of FOXB1 and FOXB2 has been implicated in the development and progression of various cancers, making them attractive targets for cancer research.
This antibody enables researchers to detect and analyze FOXB1 and FOXB2 proteins in different cell types, providing valuable insights into their functions and potential therapeutic implications in cancer treatment.Studying the expression and activity of FOXB1 and FOXB2 is crucial for understanding their roles in normal development and disease states, particularly in oncology. The FOXB1/FOXB2 Antibody (PAC021934) offers researchers a reliable tool for investigating the functions of these transcription factors, advancing knowledge in the fields of developmental biology, cancer biology, and potential therapeutic strategies targeting FOXB1 and FOXB2.
Antibody Name:
FOXB1/FOXB2 Antibody (PACO21934)
Antibody SKU:
PACO21934
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human FOXB1/2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells, using FOXB1/2 antibody.
Background:
Transcription factor. Cascio S.M., Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Synonyms:
Forkhead box protein B1/2; Transcription factor FKH-5; FOXB1/2; FKH5;
UniProt Protein Function:
FOXB1:
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component: nucleus
Molecular Function:sequence-specific DNA binding
Biological Process: lactation; transcription from RNA polymerase II promoter; floor plate development; somitogenesis; thalamus development; regulation of transcription from RNA polymerase II promoter; axon target recognition; spinal cord development; mammilary body development; midbrain development; visual learning; negative regulation of neuron apoptosis; hypothalamus cell migration; urogenital system development; telencephalon cell migration
