The GDF7 Polyclonal Antibody (PACO06927) is a valuable tool for researchers studying GDF7, a member of the bone morphogenetic protein (BMP) family involved in skeletal development and regeneration. This rabbit polyclonal antibody is highly specific to human samples and is validated for use in Western blot applications.GDF7, also known as Growth Differentiation Factor 7, plays a crucial role in bone and cartilage formation, making it a key target for research in orthopedics, tissue engineering, and regenerative medicine. By binding to the GDF7 protein, this antibody enables the detection and analysis of GDF7 in various cell types, providing valuable insights into its function and potential therapeutic applications.
Understanding the role of GDF7 in skeletal development and repair is important for advancing treatments for bone diseases, fractures, and degenerative joint conditions. By using the GDF7 Polyclonal Antibody, researchers can further investigate the mechanisms underlying GDF7's effects on bone formation and regeneration, ultimately leading to innovative therapies for musculoskeletal disorders.
Antibody Name:
GDF7 Antibody (PACO06927)
Antibody SKU:
PACO06927
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human GDF-7.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
Western Blot analysis of HELA cells using GDF-7 Polyclonal Antibody.
Synonyms:
GDF7; Growth/differentiation factor 7; GDF-7
UniProt Protein Function:
GDF7: May play an active role in the motor area of the primate neocortex. Belongs to the TGF-beta family.
UniProt Protein Details:
Protein type:Cytokine; Secreted; Secreted, signal peptide; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2p24.1
Cellular Component: extracellular space
Molecular Function:cytokine activity; growth factor activity; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding
Biological Process: activin receptor signaling pathway; axon guidance; BMP signaling pathway; branching morphogenesis of a tube; cell development; cell fate commitment; epithelial cell differentiation; forebrain morphogenesis; gland morphogenesis; growth; midbrain development; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; reproductive structure development; roof plate formation; spinal cord association neuron differentiation
NCBI Summary:
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]
