The GDF7 Polyclonal Antibody (PACO22355) is specifically designed for researchers studying Growth Differentiation Factor 7 (GDF7), a member of the TGF-beta superfamily known for its role in regulating cell growth and differentiation. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the GDF7 protein, researchers can accurately detect and analyze its presence in a variety of cell types, making it an essential tool for studies in developmental biology and tissue regeneration.
GDF7 is a key signaling molecule that plays a crucial role in skeletal and joint development, making it a promising target for research on musculoskeletal disorders and regenerative medicine. Its ability to regulate the growth and differentiation of various cell types makes it a potential candidate for therapeutic interventions aimed at promoting tissue repair and regeneration. Understanding the function of GDF7 is essential for developing novel treatments for conditions such as osteoarthritis, bone fractures, and other degenerative diseases.
Antibody Name:
GDF7 Antibody (PACO22355)
Antibody SKU:
PACO22355
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human GDF7.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HT-29 cells, using GDF7 antibody.
Background:
May play an active role in the motor area of the primate neocortex By similarity.
Synonyms:
Growth/differentiation factor 7; GDF-7;
UniProt Protein Function:
GDF7: May play an active role in the motor area of the primate neocortex. Belongs to the TGF-beta family.
UniProt Protein Details:
Protein type:Cytokine; Secreted; Secreted, signal peptide; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2p24.1
Cellular Component: extracellular space
Molecular Function:cytokine activity; growth factor activity; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding
Biological Process: activin receptor signaling pathway; axon guidance; BMP signaling pathway; branching morphogenesis of a tube; cell development; cell fate commitment; epithelial cell differentiation; forebrain morphogenesis; gland morphogenesis; growth; midbrain development; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; reproductive structure development; roof plate formation; spinal cord association neuron differentiation
NCBI Summary:
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]
