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Key Features

GenieFluor Violet 450 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL3354)

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SKU AGEL3354
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Mouse
Isotype Mouse IgG1, k
Clone Cy34.1
Conjugation AFViolet 450
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Description

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GenieFluor Violet 450 Anti-Mouse CD22 Antibody [Cy34.1]

The GenieFluor Violet 450 Anti-Mouse CD22 Antibody (CY34.1) (AG2354) from AssayGenie is a high-quality monoclonal antibody specifically designed for research applications involving CD22, a cell surface protein expressed on B cells. This antibody, developed for use in mouse samples, is highly reactive and validated for use in various immunofluorescence and flow cytometry assays.CD22 is a key protein involved in B cell receptor signaling and B cell development, making it a crucial target for studies in immunology and hematological research. The GenieFluor Violet 450 Anti-Mouse CD22 Antibody allows for precise detection and analysis of CD22 expression in mouse B cells, aiding researchers in understanding the role of this protein in B cell function and immune response modulation.

With its superior specificity and sensitivity, the GenieFluor Violet 450 Anti-Mouse CD22 Antibody is an essential tool for investigators studying B cell biology, antibody production, and immune system function in both normal and pathological conditions. Its reliable performance and accuracy make it a valuable asset for advancing research in fields such as immunology, oncology, and autoimmune diseases.

Product Title:GenieFluor Violet 450 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL3354
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor Violet 450 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie FluorViolet 450
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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