The GH2 Polyclonal Antibody (PACO16412) is a vital tool for researchers studying GH2, a protein known for its involvement in growth hormone regulation and cellular development. This antibody, produced in rabbits, exhibits a high level of reactivity specifically with human samples, making it an excellent choice for Western blot applications. By binding to GH2, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it an indispensable tool for studies in endocrinology and developmental biology.GH2, also referred to as growth hormone 2, plays a crucial role in promoting growth, cell division, and regeneration in the body.
Its functions are particularly important in maintaining proper hormone balance and supporting healthy tissue growth. Research on GH2 is valuable for understanding various growth-related disorders, such as dwarfism and acromegaly, as well as for exploring potential therapeutic interventions in these conditions. By elucidating the mechanisms of GH2 action, researchers can advance our knowledge of growth regulation and potentially discover new avenues for treatment in growth-related pathologies.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16412(GH2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: PACO16412(GH2 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16412(GH2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization.
Synonyms:
growth hormone 2
UniProt Protein Function:
GH2: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component: extracellular region
NCBI Summary:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]
