Anti-GH2 Antibody (PACO16412)

Antibody Name:	GH2 Antibody (PACO16412)
Antibody SKU:	PACO16412
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Fusion protein of human GH2

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16412(GH2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: PACO16412(GH2 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16412(GH2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).

Background:

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization.

Synonyms:

growth hormone 2

UniProt Protein Function:	GH2: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17q24.2 Cellular Component: extracellular region
NCBI Summary:	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]
UniProt Code:	P01242
NCBI GenInfo Identifier:	20141664
NCBI Gene ID:	2689
NCBI Accession:	P01242.3
UniProt Secondary Accession:	P01242,O14643, O14644, P09587, B1A4H5, B1A4H7,
UniProt Related Accession:	P01242
Molecular Weight:	27,101 Da
NCBI Full Name:	Growth hormone variant
NCBI Synonym Full Names:	growth hormone 2
NCBI Official Symbol:	GH2
NCBI Official Synonym Symbols:	GHL; GHV; GH-V; GHB2; hGH-V
NCBI Protein Information:	growth hormone variant
UniProt Protein Name:	Growth hormone variant
UniProt Synonym Protein Names:	Growth hormone 2; Placenta-specific growth hormone
Protein Family:	Growth hormone
UniProt Gene Name:	GH2
UniProt Entry Name:	SOM2_HUMAN

Antibodies	ELISA Kits
GH2 Antibody (PACO09462)	Human GH2 / Growth Hormone 2 ELISA Kit
	Human GH2 (Growth Hormone 2) CLIA Kit (HUES01058)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)