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Anti-GLIPR1 Antibody (CAB16490)

SKU:
CAB16490
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
$167 - $503
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Description

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Antibody Name:Anti-GLIPR1 Antibody
Antibody SKU:CAB16490
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-140 of human GLIPR1 (NP_006842.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-140 of human GLIPR1 (NP_006842.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ANIL PDIE NEDF IKDC VRIH NKFR SEVK PTAS DMLY MTWD PALA QIAK AWAS NCQF SHNT RLKP PHKL HPNF TSLG ENIW TGSV PIFS VSSA ITNW YDEI QDYD FKTR ICKK VCGH YTQ
Gene ID:11010
Uniprot:P48060
Cellular Location:Membrane, Single-pass membrane protein
Calculated MW:26kDa/30kDa
Observed MW:28kDa
Synonyms:GLIPR1, CRISP7, GLIPR, RTVP1
Background:This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
UniProt Protein Function:GLIPR1: a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q21.2

Cellular Component: membrane; plasma membrane

Biological Process: neutrophil degranulation; regulation of lipid metabolic process

NCBI Summary:This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P48060
NCBI GenInfo Identifier:110825980
NCBI Gene ID:11010
NCBI Accession:NP_006842.2
UniProt Secondary Accession:P48060,Q15409, Q969K2, A7YET6, F8VUC2,
UniProt Related Accession:P48060
Molecular Weight:28.2kD
NCBI Full Name:glioma pathogenesis-related protein 1
NCBI Synonym Full Names:GLI pathogenesis related 1
NCBI Official Symbol:GLIPR1  
NCBI Official Synonym Symbols:GLIPR; RTVP1; CRISP7  
NCBI Protein Information:glioma pathogenesis-related protein 1
UniProt Protein Name:Glioma pathogenesis-related protein 1
UniProt Synonym Protein Names:Protein RTVP-1
Protein Family:GDSL esterase/lipase
UniProt Gene Name:GLIPR1  
Anti-GLIPR1 Antibody (CAB16490)Western blot analysis of extracts of rat lung, using GLIPR1 antibody (CAB16490) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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