The GOSR1 Polyclonal Antibody (PAC013473) is a valuable tool for researchers studying the Golgi SNAP receptor complex 1 (GOSR1) protein. This antibody was developed using rabbits and exhibits high reactivity with human samples, making it ideal for Western blot applications. By targeting the GOSR1 protein, this antibody enables researchers to accurately detect and analyze GOSR1 expression in various cell types.GOSR1 is a key component of the Golgi SNARE complex, which plays a crucial role in vesicle trafficking and protein transport within cells.
Disruption of GOSR1 function has been linked to various cellular processes and diseases, making it a promising target for further investigation in the fields of cell biology and neurology. By utilizing the GOSR1 Polyclonal Antibody, researchers can gain valuable insights into the roles and mechanisms of GOSR1 in these contexts.
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
Subcellular Location:
Golgi apparatus membrane; Single-pass type IV membrane protein.
