The GPR124 Monoclonal Antibody (PACO03806) is a reliable tool for researchers studying G-protein coupled receptor 124 (GPR124), a critical molecule implicated in vascular development and blood-brain barrier integrity. This antibody, produced in mice, displays high specificity and sensitivity for detecting GPR124 in human samples, making it an essential component for studies involving angiogenesis, neurodevelopment, and neurovascular disorders.GPR124, also known as TEM5, is essential for proper blood vessel formation and maintenance, making it a promising target for therapeutic interventions in vascular-related diseases such as stroke, brain tumors, and neurodegenerative disorders.
By utilizing the GPR124 Monoclonal Antibody, researchers can accurately analyze the expression and function of GPR124 in various cell types and tissues, advancing our understanding of its role in vascular biology and neurological health.
Antibody Name:
GPR124 Antibody
Antibody SKU:
PACO03806
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human GPR124.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8p11.23Cellular Component: cell surface; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; regulation of chemotaxis; central nervous system development; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis
