GPR124 Antibody (PACO19730)
- SKU:
- PACO19730
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | GPR124 Antibody (PACO19730) |
| Antibody SKU: | PACO19730 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human GPR124 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19730(GPR124 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse bladder tissue, Primary antibody: PACO19730(GPR124 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19730(GPR124 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies. |
| Synonyms: | G protein-coupled receptor 124 |
| UniProt Protein Function: | GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8p11.23Cellular Component: cell surface; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; regulation of chemotaxis; central nervous system development; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96PE1 |
| NCBI GenInfo Identifier: | 221222450 |
| NCBI Gene ID: | 25960 |
| NCBI Accession: | Q96PE1.2 |
| UniProt Secondary Accession: | Q96PE1,Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4, A6H8W3 D3DSW4 |
| UniProt Related Accession: | Q96PE1 |
| Molecular Weight: | 19,530 Da |
| NCBI Full Name: | G-protein coupled receptor 124 |
| NCBI Synonym Full Names: | G protein-coupled receptor 124 |
| NCBI Official Symbol: | GPR124Â Â |
| NCBI Official Synonym Symbols: | TEM5Â Â |
| NCBI Protein Information: | G-protein coupled receptor 124; tumor endothelial marker 5 |
| UniProt Protein Name: | G-protein coupled receptor 124 |
| UniProt Synonym Protein Names: | Tumor endothelial marker 5 |
| Protein Family: | |
| UniProt Gene Name: | GPR124Â Â |
| UniProt Entry Name: | GP124_HUMAN |
| Antibodies | ELISA Kits |
| GPR124 Antibody (PACO03806) | Human GPR124 (G Protein Coupled Receptor 124) ELISA Kit (HUFI03421) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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