The Anti-GPR17 Antibody (CAB3897) is a highly specific tool for research involving G protein-coupled receptor 17 (GPR17), a protein involved in regulating oligodendrocyte differentiation and myelination in the central nervous system. This polyclonal antibody, raised in rabbits, is optimized for use in various applications including Western blot and immunohistochemistry.GPR17 is a key player in the process of remyelination, making it a potential target for therapeutic interventions in demyelinating diseases such as multiple sclerosis.
Studies have shown that GPR17 is upregulated in response to demyelinating lesions, indicating its role in promoting remyelination in the CNS.The Anti-GPR17 Antibody (CAB3897) enables researchers to study the expression and function of GPR17 in different cell types and tissues, providing insights into its role in myelination and potential as a therapeutic target in demyelinating disorders. Its high specificity and sensitivity make it a valuable tool for investigations in neuroscience and neurology.
Product Name:
GPR17 Rabbit Polyclonal Antibody
SKU:
CAB3897
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human GPR17 (NP_005282.1).
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane.
Purification Method:
Affinity purification
Gene ID:
2840
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GPR17 Rabbit pAb (CAB3897) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
