The Gremlin-1 Polyclonal Antibody (CAB11595) is a valuable tool for researchers studying Gremlin-1, a protein involved in developmental processes and implicated in various diseases, including cancer. This rabbit-derived antibody is highly specific to human samples and has been validated for use in applications such as Western blotting.Gremlin-1 is known for its role in regulating cell growth and differentiation, making it a key player in embryonic development and tissue regeneration. Its dysregulation has been linked to tumor progression and metastasis in various types of cancer.
Research on Gremlin-1 is crucial for understanding its mechanisms of action and potential therapeutic targets in cancer treatment.By using the Gremlin-1 Polyclonal Antibody, researchers can detect and analyze Gremlin-1 protein levels in different cell types, providing valuable insights into its function and potential as a biomarker for disease. This antibody is a valuable tool for studies in developmental biology, cancer research, and regenerative medicine.
Product Name:
GREM1 Rabbit Polyclonal Antibody
SKU:
CAB11595
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 44-143 of human GREM1 (NP_001178252.1).
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
26585
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GREM1 Rabbit pAb (CAB11595) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
