Description
GSTM1 Antibody (CAB17492)
The GSTM1 Antibody (CAB17492) is a high-quality antibody developed for reliable detection and analysis of target proteins. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications.The GSTM1 protein belongs to the GST superfamily, which is involved in the metabolism of various endogenous and exogenous substances, including carcinogens and drugs.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
| Product Name: | GSTM1 Antibody |
| SKU: | CAB17492 |
| Size: | 20μL, 100μL |
| Reactivity: | Human, Mouse, Rat |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | MPMI LGYW DIRG LAHA IRLL LEYT DSSY EEKK YTMG DAPD YDRS QWLN EKFK LGLD FPNL PYLI DGAH KITQ SNAI LCYI ARKH NLCG ETEE EKIR VDIL ENQT MDNH MQLG MICY NPEF EKLK PKYL EELP EKLK LYSE FLGK RPWF AGNK GLEK ISAY MKSS RFLP RPVF SKMA VWGN K | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | MU, H-B, GST1, GTH4, GTM1, MU-1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GSTM1 |
| Positive Sample: | HeLa, Mouse ovary, Mouse brain, Rat brain |
| Cellular Localization: | Cytoplasm. |
| Calculated MW: | 26kDa |
| Observed MW: | 28kDa |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
| Purification Method | Affinity purification |
| Gene ID | 2944 |
| RRID | AB_2769705 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using (CAB17492) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s. |
