The GZMM Antibody (PAC07422) is a powerful tool for researchers studying gastrointestinal cancer. This monoclonal antibody is highly specific to GZMM, a protease enzyme that is overexpressed in gastrointestinal tumors. By targeting GZMM, researchers can gain valuable insights into the mechanisms driving cancer growth and progression in the gastrointestinal tract.Whether analyzing patient samples or conducting in vitro studies, the GZMM Antibody offers reliable and sensitive detection of GZMM protein, making it an essential component of any cancer research program focused on gastrointestinal malignancies.
With its proven efficacy in immunohistochemistry and ELISA applications, this antibody is a valuable resource for researchers looking to unravel the complexities of gastrointestinal cancer and develop targeted therapies to combat this deadly disease.
Antibody Name:
GZMM Antibody (PACO07422)
Antibody SKU:
PACO07422
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:10000-1:20000, IHC-p:1:50-1:300
Species Reactivity:
Human
Immunogen:
Synthetic peptide from human protein at AA range: 207-256
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100.
Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100.
Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100.
GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzyme subfamily.
UniProt Protein Details:
Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
