The H2BFS Polyclonal Antibody (PACO06551) is a powerful tool for researchers interested in the H2BFS protein, a histone variant involved in chromatin structure and gene regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications. By targeting the H2BFS protein, this antibody allows for accurate detection and analysis in a variety of cells, making it an essential component for studies in epigenetics and gene expression regulation.H2BFS is a unique histone variant that plays a crucial role in modulating chromatin structure and gene transcription.
Its involvement in regulating gene expression makes it a key player in various biological processes, including development, differentiation, and disease progression. Research on H2BFS is vital for understanding the mechanisms underlying these processes and developing targeted therapies for conditions such as cancer, developmental disorders, and other diseases linked to aberrant gene regulation.Overall, the H2BFS Polyclonal Antibody (PACO06551) offers researchers a reliable tool for investigating the function and regulation of the H2BFS protein, paving the way for advancements in the field of epigenetics and gene expression control.
Synthesized peptide derived from human Histone H2B around the non-acetylation site of K12.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of MCF7 PC3 HELA cells using Histone H2B Polyclonal Antibody.
Western Blot analysis of COS7 cells using Histone H2B Polyclonal Antibody.
Synonyms:
H2BFS; Histone H2B type F-S; Histone H2B.s; H2B/s
UniProt Protein Function:
H2BFS: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytoplasm; extracellular space; nucleoplasm; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: antibacterial humoral response; defense response to Gram-positive bacterium; innate immune response in mucosa; nucleosome assembly; substantia nigra development
