The HEXA Polyclonal Antibody is a valuable tool for researchers studying HEXA, a key enzyme involved in lysosomal hydrolysis. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting HEXA in human samples, making it ideal for Western blot applications. By binding to HEXA, this antibody enables precise detection and analysis in various cell types, providing valuable insights into lysosomal function and potential therapeutic targets for lysosomal storage disorders.HEXA, also known as beta-hexosaminidase subunit alpha, plays a crucial role in breaking down complex molecules within lysosomes, contributing to cellular homeostasis and metabolism.
Dysregulation of HEXA activity is associated with lysosomal storage disorders, such as Tay-Sachs disease, highlighting the importance of studying its function and regulation. Through research using the HEXA Polyclonal Antibody, scientists can uncover new mechanisms of lysosomal degradation and potentially develop novel therapies for these devastating diseases.
Product Name:
HEXA Polyclonal Antibody
SKU:
CAB21777
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2).
This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
3073
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using HEXA Rabbit pAb (CAB21777) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
