The HIPK1 Polyclonal Antibody (PACO19759) is a valuable tool for researchers studying the HIPK1 protein, a key regulator of cell growth and apoptosis. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By detecting and binding to the HIPK1 protein, researchers can analyze its expression and function in various cell types, making it an essential tool for studies in cell biology and cancer research.HIPK1, also known as Homeodomain-interacting protein kinase 1, plays a critical role in cellular processes such as DNA damage response, apoptosis, and gene transcription.
Dysregulation of HIPK1 has been implicated in various diseases, including cancer, making it an attractive target for therapeutic interventions. Understanding the function of HIPK1 is crucial for developing targeted treatments that can inhibit its activity in cancer cells or promote its function in other contexts.Overall, the HIPK1 Polyclonal Antibody is a valuable asset for researchers investigating the role of HIPK1 in cellular functions and disease pathogenesis, providing insights that could lead to innovative therapeutic strategies in the future.
Antibody Name:
HIPK1 Antibody (PACO19759)
Antibody SKU:
PACO19759
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human HIPK1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19759(HIPK1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19759(HIPK1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
Synonyms:
homeodomain interacting protein kinase 1
UniProt Protein Function:
HIPK1: homeodomain interacting protein kinase 1 is a CMGC kinase of the DYRK family. May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor. 4 alternatively spliced isoforms of the human protein have been described.Protein type: Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; DYRK family; HIPK subfamilyChromosomal Location of Human Ortholog: 1p13.2Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: eye development; positive regulation of angiogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
