The Histone H1 Polyclonal Antibody (PACO06549) is a valuable tool for researchers studying epigenetics and chromatin structure. Histone H1 is a critical component of chromatin, involved in organizing and condensing DNA within the nucleus. This antibody, raised in rabbits, is highly specific to human histone H1 and has been validated for use in Western blot applications.Histone H1 plays a crucial role in gene regulation and chromatin compaction, making it essential for understanding the mechanisms underlying gene expression.
Dysregulation of histone H1 has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.By using the Histone H1 Polyclonal Antibody, researchers can detect and analyze histone H1 levels in different cell types and experimental conditions, providing insights into the role of histone H1 in chromatin organization and gene expression. This antibody is a valuable tool for studies in epigenetics, cancer research, and developmental biology.
H1B: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.
Molecular Function:chromatin DNA binding; histone deacetylase binding
Biological Process: establishment and/or maintenance of chromatin architecture; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; positive regulation of cell growth; positive regulation of histone H3-K9 methylation; protein stabilization
NCBI Summary:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
