The HLA-A Antibody (PAC007298) is a crucial tool for researchers studying the human leukocyte antigen (HLA) system, a group of proteins that play a key role in the immune system's ability to differentiate between self and non-self cells. This polyclonal antibody, produced in rabbits, specifically targets the HLA-A protein and is highly reactive with human samples. It has been validated for use in Western blot applications, enabling researchers to detect and analyze HLA-A expression in various cell types.The HLA system is essential for immune recognition and response, making it a critical area of study in immunology, transplantation, and autoimmune diseases.
The HLA-A molecule is particularly important for presenting antigens to T cells and initiating immune responses. By using the HLA-A Antibody, researchers can further their understanding of immune function and potentially develop new therapies for conditions related to immune dysregulation.Overall, the HLA-A Antibody (PAC007298) is a valuable tool for researchers interested in studying the HLA system and its role in immune function. Its high reactivity and specificity make it well-suited for a variety of research applications, allowing for detailed analysis of HLA-A expression and function in both normal and disease states.
Antibody Name:
HLA-A Antibody (PACO07298)
Antibody SKU:
PACO07298
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:10000
Species Reactivity:
Human
Immunogen:
Synthetic peptide from human protein at AA range: 220-270
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of HELA cells using Antibody diluted at 500. Secondary antibody was diluted at 1:20000.
Synonyms:
HLA-A HLAA
UniProt Protein Function:
Involved in the presentation of foreign antigens to the immune system.
NCBI Summary:
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
