The HMGXB4 Polyclonal Antibody (PAC062103) is a valuable tool for researchers studying the HMGXB4 protein, a member of the high mobility group protein family. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the HMGXB4 protein, this antibody allows for detection and analysis in a variety of cell types, making it suitable for studies in molecular biology and cancer research.HMGXB4 is known for its role in DNA binding and gene regulation, making it a key player in cellular processes such as transcription and chromatin organization.
Its involvement in these critical functions highlights its potential as a target for studying diseases related to gene expression dysregulation, including cancer and developmental disorders. Research on HMGXB4 may provide insights into mechanisms underlying these conditions, paving the way for potential therapeutic interventions targeting this protein.
Antibody Name:
HMGXB4 Antibody (PACO62103)
Antibody SKU:
PACO62103
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Peptide sequence from Human HMG domain-containing protein 4 protein (489-509AA)
Western Blot. Positive WB detected in: Jurkat whole cell lysate, K562 whole cell lysate. All lanes: HMGXB4 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 66 kDa. Observed band size: 66 kDa.
Background:
Negatively regulates Wnt/beta-catenin signaling during development.
Synonyms:
HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG), HMGXB4, HMG2L1 HMGBCG
UniProt Protein Function:
HMG2L1: Negatively regulates Wnt/beta-catenin signaling during development.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 22q13.1Molecular Function: DNA binding; chromatin bindingBiological Process: chromatin remodeling; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; endosome to lysosome transport
UniProt Protein Details:
NCBI Summary:
High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]
