The HOMER3 Antibody (PAC041414) is a valuable tool for researchers studying the function of the HOMER3 protein in various cellular processes. This polyclonal antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the HOMER3 protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it well-suited for studies in neuroscience, cell biology, and signal transduction research.HOMER3 is a scaffolding protein that plays a critical role in regulating synaptic plasticity, neuronal development, and intracellular signaling pathways. Its involvement in mediating protein-protein interactions and synaptic transmission makes it an essential protein for understanding brain function and potential therapeutic targets for neurological disorders.
Researchers investigating neuronal function, synaptic plasticity, and neurodevelopmental disorders will find this antibody invaluable for their studies.By utilizing the HOMER3 Antibody, researchers can gain valuable insights into the function and regulation of the HOMER3 protein, leading to a better understanding of its role in neuronal signaling and potential implications for neurodegenerative diseases and psychiatric disorders. This antibody is an essential tool for advancing research in the field of neuroscience and uncovering new therapeutic targets for neurological conditions.
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: HOMER3 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 17, 14, 36 kDa. Observed band size: 40 kDa.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO41414 at dilution of 1:100.
Background:
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
Synonyms:
Homer protein homolog 3 (Homer-3), HOMER3
UniProt Protein Function:
HOMER3: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Belongs to the Homer family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19p13.11Cellular Component: postsynaptic membrane; cytoplasm; plasma membrane; cell junction; cytosolMolecular Function: protein C-terminus binding; protein domain specific binding; protein binding; metabotropic glutatmate receptor bindingBiological Process: metabotropic glutamate receptor signaling pathway; protein targeting
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
