The HOXA1 Polyclonal Antibody (CAB6924) is a valuable tool for researchers studying the HOXA1 gene, which plays a key role in embryonic development and cell differentiation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds to the HOXA1 protein, allowing for precise detection and analysis in a variety of cell types.HOXA1 is essential for regulating the expression of genes involved in the development of the central nervous system, skeleton, and other tissues.
Dysregulation of HOXA1 has been linked to developmental disorders and cancer, making it a target of interest in biomedical research. By studying the function of HOXA1 using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.
Product Name:
HOXA1 Rabbit Polyclonal Antibody
SKU:
CAB6924
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 75-205 of human HOXA1 (NP_005513.1).
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
Purification Method:
Affinity purification
Gene ID:
3198
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HOXA1 antibody (CAB6924) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
