The HSP70 Monoclonal Antibody (CAB4777) is a valuable tool for researchers studying heat shock protein 70 (HSP70), a chaperone protein with important functions in cellular stress response and protein folding. This rabbit monoclonal antibody is highly specific for HSP70 and is validated for use in various applications, including Western blot and immunohistochemistry.HSP70 is known to play a crucial role in protecting cells from stress-induced damage and facilitating proper protein folding, making it a key player in maintaining cellular homeostasis. Dysregulation of HSP70 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
Therefore, studying the expression and function of HSP70 using a reliable antibody like CAB4777 is essential for advancing research in these areas.Whether investigating the role of HSP70 in disease pathogenesis, studying its potential as a therapeutic target, or simply exploring its basic biology, the HSP70 Monoclonal Antibody (CAB4777) offers researchers a powerful tool for accurate and specific detection of this critical protein.
Product Name:
Hsp70 Rabbit Monoclonal Antibody
SKU:
CAB4777
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 441-641 of human HSP70 (P0DMV8).
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Purification Method:
Affinity purification
Gene ID:
3303/3304
Clone Number:
ARC0208
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HSP70 Rabbit mAb (CAB4777) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
