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Anti-HTR1A Antibody (CAB2801)

SKU:
CAB2801
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
$167 - $503
Frequently bought together:

Description

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Antibody Name:Anti-HTR1A Antibody
Antibody SKU:CAB2801
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human HTR1A
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, SH-SY5Y, Mouse testis, Rat testis
Immunogen:A synthetic peptide of human HTR1A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3350
Uniprot:P08908
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:46kDa
Observed MW:46kDa
Synonyms:G-21, 5HT1a, PFMCD, 5-HT1A, 5-HT-1A, ADRBRL1, ADRB2RL1, HTR1A
Background:This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
UniProt Protein Function:5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding; serotonin receptor activity

Biological Process: vasoconstriction; G-protein coupled receptor protein signaling pathway; cell proliferation; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; regulation of dopamine metabolic process; regulation of serotonin secretion; positive regulation of cell proliferation; regulation of hormone secretion; serotonin receptor signaling pathway; serotonin metabolic process; regulation of behavior

Disease: Periodic Fever, Menstrual Cycle-dependent

NCBI Summary:This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
UniProt Code:P08908
NCBI GenInfo Identifier:231454
NCBI Gene ID:3350
NCBI Accession:P08908.3
UniProt Secondary Accession:P08908,Q6LAE7,
UniProt Related Accession:P08908
Molecular Weight:
NCBI Full Name:5-hydroxytryptamine receptor 1A
NCBI Synonym Full Names:5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
NCBI Official Symbol:HTR1A  
NCBI Official Synonym Symbols:G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1  
NCBI Protein Information:5-hydroxytryptamine receptor 1A; 5-HT1a receptor; guanine nucleotide-binding regulatory protein-coupled receptor
UniProt Protein Name:5-hydroxytryptamine receptor 1A
UniProt Synonym Protein Names:G-21; Serotonin receptor 1A
Protein Family:5-hydroxytryptamine receptor
UniProt Gene Name:HTR1A  
UniProt Entry Name:5HT1A_HUMAN
Anti-HTR1A Antibody (CAB2801)Western blot analysis of extracts of various cell lines, using HTR1A antibody (CAB2801) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min.

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