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Key Features

PerCP/Cyanine5.5 Anti-Human CD47 Antibody [CC2C6D4] (AGEL0998)

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SKU AGEL0998
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Host Species Mouse
Isotype IgG2a,k
Clone CC2C6D4
Conjugation PerCP/Cy5.5
€144 - €638
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Description

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PerCP/Cyanine5.5 Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated) is a cutting-edge tool for research involving CD47, a cell surface protein with key roles in immune response regulation and cancer biology. This monoclonal antibody, designated as CC2C6D4 (AGEL0998), is specifically designed for detecting and analyzing CD47 expression in human samples.CD47, also known as integrin-associated protein (IAP), is a multifunctional protein involved in various cellular processes, including regulation of phagocytosis and apoptosis, as well as modulation of immune responses. Its overexpression has been implicated in tumor immune evasion, making it a promising target for cancer therapy research.The CD47 Monoclonal Antibody (PERCP-Cyanine5.

5 Conjugated) exhibits high specificity and sensitivity in binding to CD47, enabling precise detection and quantification in flow cytometry and other immunological assays. Its application extends to studies in immunology, oncology, and beyond, offering researchers a valuable tool for investigating the intricate mechanisms underlying immune evasion and tumor progression mediated by CD47.By utilizing this advanced antibody, researchers can gain deeper insights into the functional roles of CD47 in health and disease, paving the way for the development of novel therapeutic strategies targeting CD47 in cancer and other pathological conditions.

Product Title:PerCP/Cyanine5.5 Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0998
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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